MEDICATION INTERACTIONS

Cannabidiol, or CBD, is typically extremely safe. That being said, many prescription and over the counter drugs can potentially interact with CBD. This can cause levels of medications to become too high or too low, both of which can lead to risks. If you are taking any medications at all, you should always consult with your physician before adding CBD products to your regimen.

The below list was compiled from Medscape. Medscape is a resource that physicians use to look up drugs, check interactions, side effects, dosage, etc. This list is for your information/education only and is not intended in any way to be medical advice. Always consult your physician if taking ANY medications. This list may not encompass every drug that can have an interaction with CBD.

Meds known to potentially interact with CBD:

abiraterone

abiraterone can increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. Consult your physician before adding CBD products.

ambrisentan

cannabidiol will increase the level or effect of ambrisentan by affecting hepatic enzyme CYP2C19 metabolism.

amiodarone

amiodarone will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

cannabidiol will increase the level or effect of amiodarone by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of amiodarone by decreasing metabolism. 

amobarbital

amobarbital will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

apalutamide

cannabidiol will increase the level or effect of apalutamide by decreasing metabolism. Modify Therapy/Monitor Closely. Cannabidiol may potentially inhibit CYP2C8 activity. Consider reducing the dose when concomitantly using CYP2C8 substrates.

aprepitant

aprepitant will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

armodafinil

armodafinil will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

atazanavir

atazanavir will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

bicalutamide

bicalutamide will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

bortezomib

bortezomib will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of bortezomib by affecting hepatic enzyme CYP2C19 metabolism. 

bosentan

cannabidiol will increase the level or effect of bosentan by decreasing metabolism. 

bupropion

cannabidiol, bupropion. affecting hepatic enzyme CYP2B6 metabolism. 

butabarbital

butabarbital will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

butalbital

butalbital will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

 

carbamazepine

carbamazepine will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

 

carisoprodol

cannabidiol will increase the level or effect of carisoprodol by affecting hepatic enzyme CYP2C19 metabolism. 

 

carvedilol

cannabidiol will increase the level or effect of carvedilol by decreasing metabolism. 

 

celecoxib

cannabidiol will increase the level or effect of celecoxib by decreasing metabolism. 

 

ceritinib

ceritinib will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

 

chloramphenicol

chloramphenicol will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

chloramphenicol will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism.

chlorpropamide

cannabidiol will increase the level or effect of chlorpropamide by decreasing metabolism.

 

citalopram

cannabidiol will increase the level or effect of citalopram by affecting hepatic enzyme CYP2C19 metabolism. 

 

clarithromycin

clarithromycin will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

 

clobazam

cannabidiol will increase the level or effect of clobazam by affecting hepatic enzyme CYP2C19 metabolism. 

 

clomipramine

cannabidiol will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2C19 metabolism. 

 

clotrimazole

clotrimazole will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

 

clozapine

clozapine will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

 

cobicistat

cobicistat will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

 

conivaptan

conivaptan will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

 

conjugated estrogens

cannabidiol, conjugated estrogens. affecting hepatic enzyme CYP1A2 metabolism. 

 

conjugated estrogens, vaginal

cannabidiol, conjugated estrogens, vaginal. affecting hepatic enzyme CYP1A2 metabolism.

 

crizotinib

crizotinib will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

 

cyclobenzaprine

cannabidiol, cyclobenzaprine. affecting hepatic enzyme CYP1A2 metabolism. 

 

cyclophosphamide

cannabidiol, cyclophosphamide. affecting hepatic enzyme CYP2B6 metabolism. 

 

cyclosporine

cyclosporine will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

 

dabrafenib

dabrafenib will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

cannabidiol will increase the level or effect of dabrafenib by decreasing metabolism.

dacarbazine

cannabidiol, dacarbazine. affecting hepatic enzyme CYP1A2 metabolism. 

dapsone

cannabidiol will increase the level or effect of dapsone by decreasing metabolism. 

darunavir

darunavir will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

dasabuvir

cannabidiol will increase the level or effect of dasabuvir by decreasing metabolism. 

delavirdine

delavirdine will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

delavirdine will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

desipramine

desipramine will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

dexlansoprazole

dexlansoprazole will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C9/10 metabolism. 

cannabidiol will increase the level or effect of dexlansoprazole by affecting hepatic enzyme CYP2C19 metabolism. 

diazepam

cannabidiol will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism.

diclofenac

cannabidiol will increase the level or effect of diclofenac by decreasing metabolism. 

diltiazem

diltiazem will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

doxepin cream

cannabidiol, doxepin cream. affecting hepatic enzyme CYP1A2 metabolism. 

doxycycline

doxycycline will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

dronabinol

cannabidiol will increase the level or effect of dronabinol by decreasing metabolism. 

dronedarone

dronedarone will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

duloxetine

cannabidiol, duloxetine. affecting hepatic enzyme CYP1A2 metabolism. 

efavirenz

efavirenz will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

efavirenz will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

cannabidiol, efavirenz. affecting hepatic enzyme CYP2B6 metabolism. 

enzalutamide

enzalutamide will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

enzalutamide will decrease the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of enzalutamide by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C8 activity. 

erythromycin base

erythromycin base will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

erythromycin ethylsuccinate

erythromycin ethylsuccinate will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

erythromycin lactobionate

erythromycin lactobionate will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

erythromycin stearate

erythromycin stearate will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

escitalopram

cannabidiol will increase the level or effect of escitalopram by affecting hepatic enzyme CYP2C19 metabolism. 

esketamine intranasal

esketamine intranasal, cannabidiol. Either increases toxicity of the other by sedation. 

eslicarbazepine acetate

eslicarbazepine acetate will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

esomeprazole

esomeprazole will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of esomeprazole by affecting hepatic enzyme CYP2C19 metabolism. 

estradiol

cannabidiol, estradiol. affecting hepatic enzyme CYP1A2 metabolism. 

estrogens conjugated synthetic

cannabidiol, estrogens conjugated synthetic. affecting hepatic enzyme CYP1A2 metabolism.

etravirine

etravirine will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

etravirine will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

cannabidiol will increase the level or effect of etravirine by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of etravirine by decreasing metabolism. 

fenofibrate

cannabidiol will increase the level or effect of fenofibrate. Cannabidiol may potentially inhibit UGT1A9 activity. 

flibanserin

cannabidiol will increase the level or effect of flibanserin by affecting hepatic enzyme CYP2C19 metabolism. 

fluconazole

fluconazole will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

fluconazole will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

fluoxetine

fluoxetine will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of fluoxetine by decreasing metabolism. 

flutamide

cannabidiol, flutamide. affecting hepatic enzyme CYP1A2 metabolism. 

fluvastatin

cannabidiol will increase the level or effect of fluvastatin by decreasing metabolism. 

fluvoxamine

fluvoxamine will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

fluvoxamine will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol, fluvoxamine. affecting hepatic enzyme CYP1A2 metabolism.

fosamprenavir

fosamprenavir will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

fosphenytoin

fosphenytoin will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

cannabidiol will increase the level or effect of fosphenytoin by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of fosphenytoin by decreasing metabolism. 

fostamatinib

fostamatinib will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

gemfibrozil

gemfibrozil will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of gemfibrozil. Cannabidiol may potentially inhibit UGT2B7 activity. 

glimepiride

cannabidiol will increase the level or effect of glimepiride by decreasing metabolism. 

glipizide

cannabidiol will increase the level or effect of glipizide by decreasing metabolism. 

glyburide

cannabidiol will increase the level or effect of glyburide by decreasing metabolism. 

grapefruit

grapefruit will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

haloperidol

haloperidol will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

idelalisib

idelalisib will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

ifosfamide

cannabidiol will increase the level or effect of ifosfamide by affecting hepatic enzyme CYP2C19 metabolism. 

iloperidone

iloperidone will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

imatinib

imatinib will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

cannabidiol will increase the level or effect of imatinib by decreasing metabolism. 

imipramine

cannabidiol will increase the level or effect of imipramine by affecting hepatic enzyme CYP2C19 metabolism. 

indinavir

indinavir will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

irinotecan

cannabidiol, irinotecan. affecting hepatic enzyme CYP2B6 metabolism. 

isoniazid

isoniazid will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

isoniazid will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

isotretinoin

cannabidiol will increase the level or effect of isotretinoin by decreasing metabolism. 

itraconazole

itraconazole will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

ketamine

cannabidiol will increase the level or effect of ketamine by decreasing metabolism. 

ketoconazole

ketoconazole will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

lacosamide

cannabidiol will increase the level or effect of lacosamide by decreasing metabolism. 

lamotrigine

cannabidiol will increase the level or effect of lamotrigine. Cannabidiol may potentially inhibit UGT2B7 activity. 

lansoprazole

lansoprazole will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of lansoprazole by affecting hepatic enzyme CYP2C19 metabolism. 

lapatinib

lapatinib will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

lesinurad

cannabidiol will increase the level or effect of lesinurad by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity.

letermovir

letermovir will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

lidocaine

cannabidiol, lidocaine. affecting hepatic enzyme CYP1A2 metabolism. 

lopinavir

lopinavir will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

loratadine

loratadine will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism.

lorazepam

cannabidiol will increase the level or effect of lorazepam by decreasing metabolism. Cannabidiol may potentially inhibit UGT2B7 activity. 

losartan

cannabidiol will increase the level or effect of losartan by decreasing metabolism. 

lumacaftor/ivacaftor

lumacaftor/ivacaftor will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

mephobarbital

cannabidiol will increase the level or effect of mephobarbital by affecting hepatic enzyme CYP2C19 metabolism. 

mestranol

cannabidiol will decrease the level or effect of mestranol by decreasing metabolism.

metaxalone

cannabidiol, metaxalone affecting hepatic enzyme CYP1A2 metabolism. 

methadone

cannabidiol will increase the level or effect of methadone by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C8 activity. 

methsuximide

cannabidiol will increase the level or effect of methsuximide by affecting hepatic enzyme CYP2C19 metabolism. 

 

metronidazole

metronidazole will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

 

mexiletine

cannabidiol, mexiletine. affecting hepatic enzyme CYP1A2 metabolism. 

 

miconazole oral

miconazole oral will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of miconazole oral by decreasing metabolism.

mifepristone

mifepristone will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

mirtazapine

cannabidiol, mirtazapine. affecting hepatic enzyme CYP1A2 metabolism.

mitotane

mitotane will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

modafinil

modafinil will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. 

montelukast

cannabidiol will increase the level or effect of montelukast by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity. 

morphine

cannabidiol will increase the level or effect of morphine. Cannabidiol may potentially inhibit UGT2B7 activity. 

nafcillin

nafcillin will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

nateglinide

cannabidiol will increase the level or effect of nateglinide by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity.

nefazodone

nefazodone will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

nelfinavir

nelfinavir will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

cannabidiol will increase the level or effect of nelfinavir by affecting hepatic enzyme CYP2C19 metabolism. 

netupitant/palonosetron

netupitant/palonosetron will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

nevirapine

nevirapine will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

nicardipine

nicardipine will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

olanzapine

cannabidiol, olanzapine. affecting hepatic enzyme CYP1A2 metabolism. 

ombitasvir/paritaprevir/ritonavir

cannabidiol will increase the level or effect of ombitasvir/paritaprevir/ritonavir by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C8 activity.

ombitasvir/paritaprevir/ritonavir & dasabuvir

cannabidiol will increase the level or effect of ombitasvir/paritaprevir/ritonavir & dasabuvir by decreasing metabolism. 

omeprazole

omeprazole will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of omeprazole by affecting hepatic enzyme CYP2C19 metabolism. 

osimertinib

osimertinib will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

ospemifene

cannabidiol will increase the level or effect of ospemifene by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of ospemifene by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity. 

oxcarbazepine

oxcarbazepine will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

paclitaxel

cannabidiol will increase the level or effect of paclitaxel by decreasing metabolism.

paclitaxel protein bound

cannabidiol will increase the level or effect of paclitaxel protein bound by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C8 activity.

pantoprazole

pantoprazole will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of pantoprazole by affecting hepatic enzyme CYP2C19 metabolism. 

pentamidine

cannabidiol will increase the level or effect of pentamidine by affecting hepatic enzyme CYP2C19 metabolism. 

pentobarbital

pentobarbital will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

phenobarbital

phenobarbital will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

cannabidiol will increase the level or effect of phenobarbital by affecting hepatic enzyme CYP2C19 metabolism. 

phenytoin

phenytoin will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

cannabidiol will increase the level or effect of phenytoin by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of phenytoin by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity. 

pimozide

cannabidiol, pimozide. affecting hepatic enzyme CYP1A2 metabolism. 

pioglitazone

cannabidiol will increase the level or effect of pioglitazone by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C8 activity.

pirfenidone

cannabidiol, pirfenidone. affecting hepatic enzyme CYP1A2 metabolism. 

pomalidomide

cannabidiol, pomalidomide. affecting hepatic enzyme CYP1A2 metabolism. 

posaconazole

posaconazole will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

progesterone intravaginal gel

cannabidiol will increase the level or effect of progesterone intravaginal gel by affecting hepatic enzyme CYP2C19 metabolism.

progesterone micronized

cannabidiol will increase the level or effect of progesterone micronized by affecting hepatic enzyme CYP2C19 metabolism. 

propofol

propofol will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of propofol by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity. 

cannabidiol will increase the level or effect of propofol. Cannabidiol may potentially inhibit UGT1A9 activity. 

propranolol

cannabidiol, propranolol. affecting hepatic enzyme CYP1A2 metabolism. 

quinupristin/dalfopristin

quinupristin/dalfopristin will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

rabeprazole

rabeprazole will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of rabeprazole by affecting hepatic enzyme CYP2C19 metabolism. 

ramelteon

cannabidiol, ramelteon. affecting hepatic enzyme CYP1A2 metabolism. 

rasagiline

cannabidiol, rasagiline. affecting hepatic enzyme CYP1A2 metabolism. 

repaglinide

cannabidiol will increase the level or effect of repaglinide by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C8 activity. 

ribociclib

ribociclib will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

rifampin

rifampin will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

cannabidiol, rifampin. affecting hepatic enzyme CYP2B6 metabolism.

rifapentine

rifapentine will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

riluzole

cannabidiol, riluzole. affecting hepatic enzyme CYP1A2 metabolism. 

riociguat

cannabidiol will increase the level or effect of riociguat by decreasing metabolism. 

ritonavir

ritonavir will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

ropinirole

cannabidiol, ropinirole. affecting hepatic enzyme CYP1A2 metabolism. 

ropivacaine

cannabidiol, ropivacaine. affecting hepatic enzyme CYP1A2 metabolism.

rosiglitazone

cannabidiol will increase the level or effect of rosiglitazone by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C8 activity.

saquinavir

saquinavir will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

schisandra

schisandra will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

secobarbital

secobarbital will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

 

selegiline

cannabidiol, selegiline. affecting hepatic enzyme CYP2B6 metabolism. 

 

selexipag

cannabidiol will increase the level or effect of selexipag by decreasing metabolism. 

 

sertraline

sertraline will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

cannabidiol will increase the level or effect of sertraline by affecting hepatic enzyme CYP2C19 metabolism.

 

St John's Wort

St John’s Wort will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

sulfadiazine

cannabidiol will increase the level or effect of sulfadiazine by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity. 

sulfisoxazole

cannabidiol will increase the level or effect of sulfisoxazole by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity. 

tacrine

cannabidiol, tacrine. affecting hepatic enzyme CYP1A2 metabolism. 

tamoxifen

cannabidiol will increase the level or effect of tamoxifen by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity. 

tasimelteon

cannabidiol, tasimelteon. affecting hepatic enzyme CYP1A2 metabolism. 

tetracycline

tetracycline will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

theophylline

cannabidiol, theophylline. affecting hepatic enzyme CYP1A2 metabolism. 

thiothixene

cannabidiol, thiothixene. affecting hepatic enzyme CYP1A2 metabolism.

ticlopidine

ticlopidine will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

tipranavir

tipranavir will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

tizanidine

cannabidiol, tizanidine. affecting hepatic enzyme CYP1A2 metabolism. 

tofacitinib

cannabidiol will increase the level or effect of tofacitinib by affecting hepatic enzyme CYP2C19 metabolism. 

tolbutamide

cannabidiol will increase the level or effect of tolbutamide by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity.

torsemide

cannabidiol will increase the level or effect of torsemide by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity. 

 

tranylcypromine

tranylcypromine will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

 

treprostinil

cannabidiol will increase the level or effect of treprostinil by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C8 activity.

 

tretinoin

cannabidiol will increase the level or effect of tretinoin by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C8 activity.

trifluoperazine

cannabidiol, trifluoperazine. affecting hepatic enzyme CYP1A2 metabolism.

trimethoprim

cannabidiol will increase the level or effect of trimethoprim by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity.

trimipramine

cannabidiol will increase the level or effect of trimipramine by affecting hepatic enzyme CYP2C19 metabolism. 

velpatasvir

cannabidiol, velpatasvir. affecting hepatic enzyme CYP2B6 metabolism. 

cannabidiol will increase the level or effect of velpatasvir by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C8 activity. 

verapamil

verapamil will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

voriconazole

voriconazole will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 

voriconazole will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of voriconazole by affecting hepatic enzyme CYP2C19 metabolism. 

cannabidiol will increase the level or effect of voriconazole by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity. 

voxilaprevir

cannabidiol, voxilaprevir. affecting hepatic enzyme CYP1A2 metabolism. 

cannabidiol will increase the level or effect of voxilaprevir by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C8 activity. 

warfarin

cannabidiol will increase the level or effect of warfarin by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity. 

zafirlukast

cannabidiol will increase the level or effect of zafirlukast by decreasing metabolism. Cannabidiol may potentially inhibit CYP2C9 activity.